Geroscience

Simply said, technology to prolong life or even the possibility of reverse aging all together.

There are 6 companies spearheading this research at the moment, C360Health, Cleara Biotech, Oisin Biotech, Sierra Sciences, Google's Calic, Craig Ventor's Human Longevity Inc.

These are amazing companies to keep an eye out for the future. However there have already been many breakthroughs in the field of longevity and reverse aging and I like to introduce them here for you.

Peter de Keizer Cleara Biotech.com

Calico is a Google company that is tackling aging, one of life’s greatest mysteries. Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.

Calico's website: https://www.calicolabs.com

Craig Venter

Welcome to the era of health intelligence from Craig Venter. Human Longevity, Inc. (HLI) is revolutionizing human health by generating more data and deeper understanding into what can keep you living healthier longer. HLI’s scientists have created the world’s largest database of sequenced genomes and phenotypic (physical traits) data, to uncover unprecedented insights capable of transforming health care from reactive to proactive.

Human Longevity Inc website: https://www.humanlongevity.com

Oisin Biotechnologies

Oisín Biotechnologies' ground-breaking research and technology is demonstrating that the solution to mitigating the effects of age-related diseases is to address the damage created by the aging process itself. We invite you to see how.

Aging is a complex and difficult topic that has been the center of attention of many scientists for centuries. That's also what Bill Andrews, Ph.D., the founder of Sierra Sciences, has made his challenge to solve. Aging isn't an accident. We age because our telomeres get shorter and our cells age. Every time our cells divide, our telomeres get shorter and our cells age. Aging is also the cause of a lot of diseases. Research suggests that control of the telomere length has the potential to treat many diseases linked to aging. This is what SIERRA SCIENCES group of scientists led by Dr Andrews has been working on for the last two decades and is close to finding cures that will change the way we live our life forever.

---

https://sirtlabcorp.com

Sirtuin 6 (SIRT6) longevity and liver health. First human trials started this summer 2023.

---

Dr. Andreas Beyer

A recent study in 2023 from the University of Cologne in Germany, published in the journal Nature, has made significant discoveries about the ageing process. The research, led by Dr. Andreas Beyer, found that as we age, gene transcription—the process where a cell creates an RNA copy of DNA—becomes faster but less accurate, leading to errors. This could play a role in many diseases associated with ageing. Previously, studies primarily examined which genes were activated or deactivated with age. Beyer's focus on transcription itself is groundbreaking.

Transcription is crucial as the RNA copies hold genetic information to produce new proteins, vital for cell function and health. Different cells in our body, like nerve or blood cells, require varied gene transcriptions. Beyer termed the mechanism responsible for this transcription process as Pol II (RNA polymerase II). His team found that increased speed in transcription in Pol II with age results in more mistakes—similar to genome sequence mutations.

Earlier research suggested that low-calorie diets and inhibiting insulin signaling can delay ageing. Beyer’s team studied these factors and their influence on Pol II’s speed using genetically modified worms, mice, and fruit flies. They observed that slowing down Pol II led to fewer errors and increased lifespan by 10-20%. Testing human blood samples, the team noted similar results between young and older cells. According to Argyris Papantonis, a principal investigator, these findings indicate a broader implication for understanding ageing across species. Beyer believes that interventions like a healthy diet could improve transcription quality, offering potential ways to delay ageing or prevent diseases like cancer.

---

Below you find 10 new startups that are also really promising:

---

Charlene Levitan

Charlene Levitan who studies centenarians (people who live beyond the 100) for the Sydney Centenarian Study, revealed that only about 30% of longevity is determined by our genes.

We can’t choose our parents, but we can choose our lifestyle.

In another longevity project, National Geographic writer Dan Buettner has uncovered the places around the globe where the residents have the greatest life expectancy and where more people reach age 100 than anywhere else. In his book The Blue Zones: Lessons for Living Longer from the People Who’ve Lived the Longest, Buettner describes five ‘blue zones’ of longevity:

Barbagia region of Sardinia Mountainous highlands of inner Sardinia with the world’s highest concentration of male centenarians. Ikaria, Greece Aegean Island with one of the world’s lowest rates of middle age mortality and the lowest rates of dementia. Nicoya Peninsula, Costa Rica World’s lowest rates of middle age mortality, second highest concentration of male centenarians. Seventh Day Adventists Highest concentration is around Loma Linda, California. They live 10 years longer than their North American counterparts Okinawa, Japan Females over 70 are the longest-lived population in the world.

Dan Buettner and his team of Blue Zones researchers spent time in each of these zones, and have identified the secrets to longevity. Mind you, I’d say they’re more common sense than secret!

1) Be part of a group and be social, have a purpose and share this purpose while putting your family first.

2) Also have a very relaxed outlook on life that things will work out anyway. (in other words stress free)

3) As far as lifestyle goes, be active and eat more plants and do not overeat.

That's it.

Today, about 450 people in the world are past 110, according to The Gerontology Project, an Atlanta-based independent research group that has tracked and documented the ages of these super centenarians. Many more have hit the full-century mark: about 50,000 people in the U.S. alone and 100,000 worldwide, according to the Boston-based New England Centenarian Study.

Photojournalist Jerry Friedman has searched out 50 of the oldest of the old, and shares his photographs -- as well as their stories -- in his book, Earth's Elders: The Wisdom of the World's Oldest People. He found many in the U.S. -- in the Upper Midwest, the Northeast, the deep South -- and also in India, Japan, Spain, Portugal, Germany, and Mongolia. From these encounters, Friedman uncovered common threads -- personal traits, habits, and attitudes that may offer secrets to longevity. What he found, scientists tell WebMD, matches what the research studies are showing. There is a pattern to longevity that we can control, to some extent. Quite simply, it means taking better care of ourselves -- plus staying active, curious, and confident that things will work out (in other words stress free). Basically the same finding as in the blue zones.

Looking at diet, environmental toxins, radiation exposure such as cell phones, WiFi etc. and even our inherited genes, one can conclude it hardly influences longevity. Just look at the map below - Australia, average age 83 and climbing while their diet is meat and diary. Singapore and Japan also having an average age of 83 full of radiation exposure. Canada average age 82 and rising while the USA is 76.5 and declining - why? Well looking at this data it becomes clear that education, finances and a happy life (stress free) play a big role.

Click here map to see the Life expectancy over time

As you can see, almost the same as life expectancy. In other words, The more money you have, the older you get.

Click here to see the population growth on planet earth.

The map itself  is of 2020 showing you the density of humans on our planet.

If you have a look at the  interactive map above, 150 years ago, the rich and educated countries had an average age of 40, while the poor countries were way below that. That is half of what it is now !
In other words our species (Homo Sapiens) that have wandered the earth for over  350.000 years only gained an average life expectancy above 40 a 150 years ago. Look at our eyes and teeth, they are made to last 40 years, not 80.

Leading causes of death per country 2019

All developed coutries die from Coronary Heart deseases and strokes. All blood related with a close second being cancer. It is becoming more clear that not fat but sugar is the main problem for both cancer and heart disease.

But there is more to the story. Many Indian and Tibetan masters have gone far beyond their normal expiry date as well. This had nothing to do with their social behavior, family first and their healthy way of living. Most of them were wondering the earth naked, isolated from the world and did not eat nor drink anything or very little. This again links to a sugar cause with stress for early death causes.

Below are 5 famous examples:

If you sum it all up, it is not the food, genes, toxins, radiation or  genes that predict a long life span but stress, be it external or internal !
Yes eating high amounts of sugar and fried foods increases internal oxidative stress, just like smoking does and a nasty workplace or environment creates a high amount of external stress.

So knowing you should reduce stress are their ways of reducing internal stress as well with new technology? And if so, are they effective at increasing our life expectancy?

The new age

Technology rewriting limits and possibilities...

In the past 10 years or so, many technological breakthroughs have happened in the field of anti-aging.  One of the most amazing ones is FOXO4-dri, a peptide found by Peter de Kijzer from the Erasmus MC in Rotterdam, Netherlands. This little peptide gets rid of senescent cells (broken ageing cells) and brings the whole body back  to youth. More info here: www.foxo4dri.com

There is so much happening right now that extreme longevity is no more a dream but slowly approaches reality. Just look at Floyd Romesberg who put together a whole new life-form in 2017 by adding 2 new letters to our DNA code (NaM (X) and TPT3 (Y)), making it possible for the creation of 8 times more amino-acids then before.

Another amazing product that doubles life span is all the test subjects so far like mice, rats, cats and dogs is C60 ! This molecule gets rid of oxidative stress (internal stress) and keeps the cells alive a lot longer.

Another new company that does similar research is the Dog aging project.

With other words, so many poeple working on different angles on the same problem, it is mere time untill we have cracked the aging problem.

Will this be your future?

---

Fountain of youth pill 2023

The "fountain of youth" pill might soon become a reality, thanks to a tiny marine creature called Hydractinia symbiolongicarpus. These jellyfish-like creatures have amazing regenerative abilities and could have significant implications for healthcare and anti-aging treatments.

Researchers discovered Hydractinia's regenerative powers by analyzing pieces of RNA related to gene aging. The study revealed that understanding these biological processes is crucial for human health and disease control.

So, how can a jellyfish-like animal lead to a "fountain of youth" pill? Well, while humans can regenerate certain tissues, animals like salamanders and zebrafish can replace entire organs. Simple creatures like Hydractinia show extreme regenerative capabilities.

By studying these distant animal relatives, scientists hope to unlock the secrets of regeneration and aging. Learning how senescence (the process of aging in cells) can be beneficial in certain animals might lead to breakthroughs in regenerative medicine and age-related disease research.

Hydractinia uses stem cells to regenerate, and researchers have identified similar genes in humans. Understanding how these genes work in Hydractinia could offer insights into the aging process in humans.

Though there's still much to learn, this research offers promising avenues for understanding human biology and potentially developing rejuvenating treatments.

The immortal Jellyfish (Turritopsis Dohrnii) - Yes it never dies...

Meet Hydra, the immortal polyp (it only has stem cells, no normal cells)
- Yes it also never dies...

Below you find the list of supplements that I use as of 2025. It has been a long search for the perfect combination of herbs and supplements as many of them are not compatible, do not work effectively, are an overkill or create side effects that are not desirable. Also many herbs do the same thing or become obsolete in combination with other herbs, so only the best and most effective herbs are used in this list. However as everyone is different, it might not be your perfect combination, this is something you have to work out for yourself.

The main product is C60 lipofullerene and backup being MitoQ. Basically this is the best and only product really needed in the list and includes the L-carnosine, PQQ and MNM. Fisetin is a very good anti-senolitic and Epitide is one of the best telomerase product, but iboga is better. Camu Camu is for better sleep as vitamin C is the starting link to creating melatonin. Lions mane is for brain health. Fasting is good for stem cells.

Polypodium from Heliocare and Smart are the best for when you are exposed to the sun and L-lysine is very good if you are sick or want an immunity booster. Lions mane and many other products are already included in wizard sciences. DS-01 seeds is for boossting your probiotic

---

TOP longevity and reverse aging supplements 2025:

Nano molecules targeting oxidative stress

There is a new revolution on the horizon and that is deep free radical protection in the form of complex molecules that stay inside the cells and protect them within and where needed turn into pro-oxygens to act like a senolytic (explained later). The best examples are LF-SQ and SkQ1.

LF-SQ is a derivative of Carbon-60 or C60. C60 on the market has been proven in 2019 not effective but LF-SQ is the opposite. It has been shown on every animal lab test that it increases life span by almost 100% and in dogs and humans it does miracles including anti-cancer behavious with the right diet.

I do not take all the anti-oxygens anymore like I used to. For example I stopped taking Astaxanthin, Centrophenoxine, Tocotrienols, Luteolin, Neuro-Mag and even PQQ and Theracurmin.  These are all powerful anti-oxygens but I got ringing in my ears and something did not feel right in combination with C60, so I stopped and it feels a lot better. From my own research I think I was  overdosing the body with anti-oxygens.

LF-SQ - (LipoFullerene)

Found in the product: C60 Wizard sciences

C360 REVIVE is by far the single best product of this whole webpage.
If you consider buying anything to prolong life, just go for this one. Its main ingrediant is LipoFullerene with serratiopeptidase (an enzime that eats scar tissue), L-carnosine (gets rid of old weak cells) and CoQ10 (Coenzyme Q10 is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance.)

If you dissolve Fullerene (C60) in squalane (C30H62) at near-saturated or higher concentrations you get LipoFullerene (LF-SQ).

LipoFullerene

Basically LF-SQ is an inflammation fighting and extremely effective anti-oxidant molecule that almost doubles life span in most animals and even reverses aging symptoms and looks.

Ian Mitschell is also working on linking fructose to Carbon-60 as an effective anti-cancer treatment. Products to come in the near future.

Now the second ingredient is serratiopeptidase. Be careful if you need an operation in the hospital because it keeps the blood thin. Also there has been a negative reports with serratiopeptidase that it spreads abscess into deeper planes but with the combination of LF-SQ and the low dosage it seems to have very good health benefits in general.

C360 Rejuvinate is for women and has Hyaluronic acid added to it for better skin health and faster wound healing.

 

Ian Mitschell interview

SKQ1 (Visomitin)

plastoquinonyl-decyl-triphenylphosphonium

www.kalinka-store.com € 75,-

Ingredients: Aqua, Pentylene glycol, Propylene glycol, Ceratonia Siliqua. Pectin, Algin, Caprylic Triglyceride, Spilanthes Acmella flower extract, Caprylyl Methicone, Hydrogenated Polydecene, Ethylhexylglycerine, Plastoquinonyldecyltriphenylphosphonium Bromide (PDTP)

Plastomitin

An amazing SkQ1 product awaits approval and is called Plastomitin. See www.mitotechpharma.com for more info on that and the video below. This product makes Myricetin obsolete.

But it seems C60 in squalane (LF-SQ) is already doing what Plastomitin promises to do...

---

Senolytics

By treating one of the root causes of aging – senescent cells (old cells that do not function correctly anymore) – a new class of drugs, known as senolytics, has the potential to treat a wide range of age-related diseases rather than the traditional approach of dealing with them one at a time.

As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known as apoptosis and are disposed of by the immune system. Unfortunately, as we age, increasing numbers of these cells evade apoptosis and linger in the body. These senescent cells do not divide or support the tissues of which they are a part; instead, they emit a range of harmful chemical signals. Their presence causes many problems, including impairing tissue repair and increasing inflammation, and is linked with the progression of osteoarthritis, atherosclerosis, cancer and other age-related diseases. As if that was not bad enough, the harmful signals created by senescent cells can also encourage other nearby cells to enter the same senescent state.

It has long been suggested that removing these problem cells could be a way to prevent or delay age-related diseases, and, indeed, positive results have been shown in mouse studies. Therapies that remove senescent cells are commonly known as senolytics. The best of them is called FOXO4-dri.

FOXO4-DRI

FOXO4-DRI (at the moment for research only)
https://www.clearabiotech.com is working on an even better version

One of the most amazing anti-aging product in the world today. For research only.

http://www.buckylabs.com/products/ 5mg

But there are alternatives, not as effective, but a lot cheaper. Navitoclax and dasatinib are the most famous in the medical field and the natural options are Quercetin, Pine pollen, Cistanche, Fisetin, Pu-Erh Black Tea, green tea, Long pepper and Reishi Mushroom. More info about senolytics can be found here.

Reprogramming senescent cells is another effective approach. Belmonte and collegues have already successfully reprogrammed senescent cells and a similar effect was found with L-Carnosine (found below in the product Nouvelle Vie).

Fisetin

Fisetin is one of the best senolytic therapies on the market today. Fisetin is a flavonol with antioxidant properties that is promoted for improving brain health, cognition and memory.
Laboratory and animal studies in the Salk Institute have found that it protects and promotes the growth of brain cells, and enhances memory in mice.

Use for 1 week and then a week break. Do NOT use together with Niacin or NMN or NR or NAM - all NAD+ precursors.

Fisetin
(www.iherb.com you can find good deals with low shipping costs)

L-Carnosine

This product is included in the C360 health.

The naturally occurring dipeptide carnosine (beta-alanyl-L-histidine) has been found to exert an anti-senescence effect when used as a dietary supplement. Carnosine clearly improved the external appearance of experimental animals and provided beneficial physiological effects, thus maintaining the animals in better condition than control animals receiving no carnosine or a mixture of beta-alanine and L-histidine.

Piperlongumine

(Pippali).

Piperlongumine (PL) is a natural product constituent of the fruit of the Long pepper (Piper longum), a pepper plant found in southern India and southeast Asia.

This pepper is tasty and is known for detoxifying the longs, it helps in removing cold and congestion.

But it also happens to be one of the better natural senolytics overall especially for tissue.

It also has anti-tumor activity as well.

Use for 1 week and then a week break. Do NOT use together with Niacin or NMN or NR or NAM - all NAD+ precursors.

€ 10,-

PolyPodium Leucotomos

(The best internal sunscreen)

The high percentage of antioxidant phenols in PL have been shown to protect skin from UV radiation and radiation in general (and thereby preventing oxidative damage). It has also been shown to help prevent sunburn and reduce the reddening of skin that can occur with sun exposure from the inside out.

Polypodium leucotomos is also taken for the treatment of inflammation and a variety of skin ailments including psoriasis, vitiligo (the loss of pigment in patches of the skin), atopic dermatitis (eczema: inflammation of the skin), and melasma (over-pigmented patches of dark skin).

DO NOT BUY FROM INDIA !

Centrophenoxine

Centrophenoxine is best known for its considerable abilities as a memory booster. Its primary action is providing additional choline and enabling the production of acetylcholine, the neurotransmitter that is most closely tied to cognitive function in general and memory in particular. But it is also known as an aggressive free radical scavenger and powerful antioxidant that protects the brain from age-related deterioration, flushes out toxins, and repairs damaged cells. It increased the lifespan in mice over 30% and counteracts brain aging.

But do not take in combination with C60, not needed and not beneficial and especially not in combination with iboga or afterwards - creates too much energy.

French Maritime Pine extract.

The best product for healthy arteries. Along with Gotu Kola, Vitamin K (Basil) and niacin (vitamin B3 flush)
you have the best natural protection for the whole cadiovascular system

porphyra umbilicalis algae with karanja vegetable oil

The best external sunscreen

This sunscreen is a medium sun protection for the body on a mineral oil form, adapted to sensitive skins. Its formula protects the skin and its DNA:- the porphyra umbilicalis algae extract (anti-UVA) and the karanja vegetable oil (anti-UVB) act like natural sun filters, allowing the protection of the cutaneous DNA against the sun rays. This sunscreen also prevents the apparition of aging signs and preserves the youthfulness of the skin. It offers a natural and even tan. Without paraben, phénoxyethanol, nano-particles, listed chemical filters. Hypoallergenic, dermatologically tested. Resistant to water. This product respects the sea and preserves corals: biodegradability tests, tests on the preservation of corals, OCDE tests.

https://www.cocooncenter.co.uk

---

DNA repair

In nature, scientists have found that there are genes that actually repair DNA and make it totally immune to cancer and protect against free radical damage, such as the BRCA1 and ATM gens found in the naked mole-rat (Heterocephalus glabe). It is also found that certain worms (Planaria) produce telomerase that keeps the stamcells forever young and repair damaged tissues by rebuilding it. Also the SOD-gene produced by the eastern oyster makes it become 500 years old as it protects the animal from free-radical damage like nothing else can.

So what can we do that is already available on the market?

Intranasel gene therapy:

In 2022 Dabbu Kumar Jaijyan used the mouse cytomegalovirus to alter the genes of mice to produce more TERT-genes (Telomerase REverse Transcriptase). This caused a 41% life extension in mice. In the next 5 years this will also become available with the human cytomegalovirus. However the Russians are already way ahead...

Epitalon is a synthetically derived peptide (AEDG peptide, Alanine, Glutamic acid, Aspartic acid, Glycine) that was discovered by the Russian scientist Professor Vladimir Khavinson. His research proved that Epitalon consists of powerful life extension and anti-aging properties. Its primary mechanism involves increasing the natural production of telomerase, allowing the replication of our DNA so that the body can grow new cells and rejuvenate the old ones. With Epitalon, there will be an increase in human lifespan, prevention of age-related diseases, improvement of skin health, and healing of injured muscle cells. (Stay away from TA65 and similar, these can actually cause cancer. Epitalon prevents cancer). Now Sierra Sciences as of November 2019 are doing trials for repairing telomers and gene therapy aiminng at reversing aging, so this company might produce supplements in the next few years that will be way better than all the other supplements here on DNA repair.

Epitide (This is the natural form of epithalon, better than the synthetic)

Stand up for anti-aging and telomere protection! We don't mean take a stand–we mean actually get out of your chair and stand up to protect your telomeres, according to research published in the British Journal of Sports Medicine. The researchers found that the less time a spent sitting, the longer his or telomeres. In fact, in this study, time spent standing was even more important than exercise for telomere protection. This is great news because most things you do sitting down (watching TV, checking email, calling a friend), you can do standing up.

Stay away from CycloAstragenol, TA65 and other Astragalus extracts though. They have no effect on the lifespan of mice, so do not waste your money on these.

Neuroprotective and anti-aging agent. NMN is a precursor of NAD+
NAD+ is the shortened name of nicotinamide adenine dinucleotide. It’s a chemical compound used by every cell in your body. It repairs DNA and keeps the cells healthy and new. Latest research shows that with this substance reverse aging can happen. There are many NAD+ precursors such as NR, NAM and Tryptophan but only NMN bypasses the NAMPT bottleneck in tissues so that restoring NAD+ to youthful levels can happen in ALL CELLS throughout the body.

Now a word of caution - Some research indicates that the reason why the body is producing less NAD+ when it gets older is to protect itself from cancer.

Vitamin B3 NIACIN is another NAD+ precursor that follows the NOVO pathway in the body (NMN follows the salvage pathway) and is a lot cheaper then NMN but does not reach all the cells in the body as it cannot bypass the NAMPT bottleneck. NR is not so effective and Nicotinamide is actually doing the opposite. So stay away from these.

Talk about the future of DNA repair, take a look at what science can do already:

Brian Madeux is the first person to have successfully completed the first gene repair treatment curing him from the Hunter syndrome.
This happened at the end of 2017 and there will be many more breakthroughs following him. Just take a look at CRISPR/Cas9 and you
will be amazed at how far we already are. Eventually changing our genes to stop aging will not be science fiction anymore but science fact
in a not too far future.

-- -- --

DREAM complex

“When we suppress the so-called DREAM complex in body cells, various repair mechanisms kick in, making these cells extremely resilient towards all kinds of DNA damage,” said Professor Dr. Björn Schumacher, Director of the Institute for Genome Stability in Aging and Disease at the University of Cologne’s CECAD Cluster of Excellence in Aging Research.

-- -- --

https://lifespanbook.com

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming. Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political risks and benefits of a world in which billions of people can live much longer and much healthier lives.

 

(Gynostemma) Tea
jiaogulan

People in the original local region of China where Gynostemma was traditionally taken were found to have longer life spans, less disease and greater vitality than just about any other people in the world. This discovery prompted Chinese and Japanese researchers to seriously study this herb, finding that certain plant saponins known as "gypenosides" seem to be responsible for the many benefits of Gynostemma. Combinations of compounds in Gynostemma appear to stop the DNA from being degraded and broken down too quickly. Gynostemma has been found to stop and even reverse the process of erosion of the telomeres. Telomeres are the ‘end caps’ on strings of DNA, and the remaining length of telomeres is a major factor governing your remaining life span. The effects of Gynostemma on telomeres make it one of the most powerful longevity substances ever known. Also a very good anti-diabetic herb.

Dragon Herbs, Spring Dragon Longevity Tea, Caffeine Free, Genostemma 20 Tea Bags € 10,- (incl. shipping & import charges)

Fasting

In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal. In both mice and a Phase 1 human clinical trial involving patients receiving chemotherapy, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for the generation of blood and immune systems, the research showed.

The study has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as people age. By outlining how prolonged fasting cycles — periods of no food for two to four days at a time over the course of six months — kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders. “We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system,” said corresponding author Valter Longo, Edna M. Jones Professor of Gerontology and the Biological Sciences at the USC Davis School of Gerontology and director of the USC Longevity Institute.

Combining Fasting with Senolytics is most likely going to be a success in life extension.

The best way to fast for detox and stem cell support is the Half-Fast by Albert Mosseri (2 weeks water fast followed by 2 weeks of daily 500 grams berries and 500 grams vegies + 10 grams mixed senolytics powder as seen above on this page)

Herbs that are not yet available but have great potential for stemcell support are Tithonia diversifolia (Tree Marigold or Mexican sunflower), Drynariae fortunei (Fortune's Drynaria Rhizome), Ferula gummosa (Galbanum), Mucuna gigantea, Dhanwantram kashaya.

 

---

Jing builders

Jing deficiency is essentially a "weak (or nearly dead) battery." One could compare Jing to the battery in a car, where Qi is like the gasoline. Most people need Yin Jing tonics first: herbs like Rehmannia root, Heshouwu, Dendrobium, Ligustrum, Rehmannia, Schizandra. These Yin Jing tonics will quickly re-establish a baseline of Jing. It is like recharging their battery. If done correctly, a person can be out of Jing deficiency danger in 100 days.

King of the locking Jing herbs is the Schizandra berry from Manchuria (not the southern variety of Schizandra commonly marketed to unknowledgeable Americans).

Schizandra stops leaking throughout the body and helps all the organs to store Jing more effectively. It is particularly powerful at storing and protecting the Jing of the Kidney.

Schizandra is the quintessence of Chinese herbs. It enters all 12 meridians, nurtures all five elements (thus the name "Five Flavor Fruit") and tonifies all Three Treasures.

---

Brain Protection
(because stem cells do not produce new brain cells)

A team of biologists has discovered how to awaken neural stem cells and reactivate them in adult mice.

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

Stem cells have the unique ability to continuously produce copies of themselves and give rise to differentiated cells with more specialized functions. Neural stem cells (NSCs) are responsible for building the brain during embryonic development, generating all the cells of the central nervous system, including neurons.

Neurogenesis capacity decreases with age

Surprisingly, NSCs persist in certain brain regions even after the brain is fully formed and can make new neurons throughout life. This biological phenomenon, called adult neurogenesis, is important for specific functions such as learning and memory processes. However, in the adult brain, these stem cells become more silent or ‘‘dormant’’ and reduce their capacity for renewal and differentiation. As a result, neurogenesis decreases significantly with age. The laboratories of Jean-Claude Martinou, Emeritus Professor in the Department of Molecular and Cellular Biology at the UNIGE Faculty of Science, and Marlen Knobloch, Associate Professor in the Department of Biomedical Sciences at the UNIL Faculty of Biology and Medicine, have uncovered a metabolic mechanism by which adult NSCs can emerge from their dormant state and become active.

‘‘We found that mitochondria, the energy-producing organelles within cells, are involved in regulating the level of activation of adult NSCs,’’ explains Francesco Petrelli, research fellow at UNIL and co-first author of the study with Valentina Scandella. The mitochondrial pyruvate transporter (MPC), a protein complex discovered eleven years ago in Professor Martinou’s group, plays a particular role in this regulation. Its activity influences the metabolic options a cell can use. By knowing the metabolic pathways that distinguish active cells from dormant cells, scientists can wake up dormant cells by modifying their mitochondrial metabolism.

---

Healthy smoothy mix for if you want more

---

Anti Aging Detox

Scientists from the University of Virginia (UVA) have identified a promising approach to delay aging by detoxifying the body of glycerol and glyceraldehyde, harmful by-products of fat that naturally accumulate over time.

The new findings come from UVA researcher Eyleen Jorgelina O’Rourke, PhD, and her team, who are seeking to identify the mechanisms driving healthy aging and longevity. Their new work suggests a potential way to do so by reducing glycerol and glyceraldehyde’s health-draining effects.

In their search for the secrets to slow down aging, O’Rourke and her graduate student Abbas Ghaddar and postdoc Vinod Mony turned to microscopic worms called C. elegans. These soil dwellers share more than 70% of our genes and are an invaluable tool for biomedical research; two Nobel prizes in medicine were awarded to discoveries made using this worm exclusively.

Prior aging research in worms, mice and human cells made O’Rourke and others in the field suspect that the key to extending lifespan was to activate autophagy, a process that renews broken and old parts in our cells. But O’Rourke and her collaborators were surprised to find that wasn’t necessary – the scientists improved the worms’ health and lifespan by 50% with no increase in autophagy at all.

They did this by capitalizing on a mechanism they discovered and named AMAR, the Sanskrit word for immortality. AMAR, in this instance, stands for “Alcohol and aldehyde-dehydrogenase Mediated Anti-aging Response.” In short, the scientists found that they could prompt an anti-aging response by putting the spurs to a particular gene, adh-1. Doing so prompted the gene to produce more of an enzyme, alcohol dehydrogenase, that prevented the toxicity caused by glycerol and, indirectly, glyceraldehyde. The result was that the worms lived longer, healthier lives.

Findings in lab models such as worms and mice don’t always hold true in people, of course. So the researchers took several more steps to see if their lead was as promising as it appeared. First, they confirmed that the enzyme had similar beneficial effects on lifespan in another lab model, yeast. Then they scoured through research looking at gene activity in creatures, including humans, who had undergone fasting or calorie restriction because both fasting and calorie restriction are known to extend healthspan and lifespan. Sure enough, the scientists found increased levels of the anti-aging enzymes in all the mammals tested, including in humans.

Kaqun

While oxygen therapies do exist, KAQUN presents a unique form of oxygen transportation that focuses on our bodies capability to equalise the low oxygen pressure in our tissues with the high oxygen content of KAQUN products. 

The result: we are able to deliver oxygen to 32 trillion cells without side effects

-- -- --

Nice to know herbs

Everyone knows sugar and teeth do not go well together. But there seems to be a solution this this problem as well. It is called KFD2-rPAc vaccine. It targets the bacteria that causes dental problems. Also a virus called ΦAPCM01 has a lot of potencial, killing the bacteria causing dental problems. Until it is available go for the fluor toothpaste!

In the next coming years also look for DIM (3,3 Diindolylmethane) in your toothpaste. It kills the streptococcus mutans biofilm that causes cavities.

---

Anti-biotics new

Nourseothricin is a natural product made by soil bacteria that are gram-positive. It is actually a mixture of antibiotics, given individual names such as streptothricin F (S-F) and streptothricin D (S-D). The S-D is toxic, however S-F not. So this might become the new anti-biotic for drug resistant bugs.

If that does not work, you also have the Phage therapy therapy. Very succesful against drug resistant bugs.

-- -- -- -- --

Products like Salacia and Caralluma are great if you also want to loose weight.

---

Raw A2 milk